Research Projects

Intramural

2026

  • Stress Granules Dysregulation as an Early Event in Hyperglycaemia-Induced Kidney Damage (Duration- 2026-2027) (PI: Dr. Ravi Shankar Singh)

2025

  • Comparative analysis of IUGR-associated mitochondrial proteome in early pregnancy”. (Duration- 2025-2027) (PI: Dr. Suman Mishra)
  • To examine the role of DEAD-box helicases in exosomal packaging of miRNAs in kidney disease. (Duration- 2025-2027) (PI: Dr. Ravi Shankar Singh)

 

2024

  • Evaluation of styrene maleic acid lipid particles prepared from Mycobacterium tuberculosis plasma membrane as a prototype vaccine against tuberculosis Duration: 2024-2026 (PI: Dr. Alok Kumar)

 

2023

  • Investigation of autophagy regulation as a potential therapeutic approach in glioblastoma. (2023-2025) (PI: Dr. Lokendra K. Sharma)

 

2021

  • Targeting of glioblastoma stem cells through modulation of mitochondrial mechanisms for developing effective therapeutic approaches. (2021-2023) (PI: Dr. Lokendra K. Sharma)

2020

  • Validation of ‘Hi-Screen” test for COVID-19 Developed at SGPGI (From 15.12.2020 to 14.12.2022) (PI: Dr. Swasti Tiwari).
  • Comparison of Cytotrophoblast Cell-Fusion Markers in Placenta of Early and Term Gestation (A Pilot Study) (From 15.12.2020 to 14.12.2022) (PI: Dr. Santosh Kumar)

2019

  • Brain Ageing Research: Role of genetic modified extra cellular vesicles (EVs) in modulation of age related chronic neuroinflammation (From 01.09.2019 to 31.08.2021) (PI:Dr. Alok Kumar).
  • Development of predictive markers for maternal and neonatal health through investigation of mitochondrial changes during pregnancy (A pilot study) (From 01.09.2019 to 31.08.2021) (PI:Dr. Lokendra Kumar Sharma).
  • Gene expression analysis during trophoblast cell fusion process (From 01.09.2019 to 31.08.2021) (PI: Dr. Santosh Kumar)

2018

  • To examine the immunomodulatory effect of Umbilical cord blood Mesenchymal stem cells on HLA matched immune cell interactions in the context of Type 1 Diabetes (From 11.10.2018 to 10.10.2020) (PI: Dr. Swasti Tiwari)

2015

  • Analysis of Ghioconeogenic enzymes in Human urinary Exosomes: Pilot study (From 20 -10-2015 to 19-10-2017) (PI: Dr. Swasti Tiwari)

2013

  • Proteomic profiling of urinary exosomes from diabetic patients with microalbuminuria- Pilot study (From 26.03.2013 to 25.03.2015) (PI: Dr. Swasti Tiwari)

2009

  • To determine the usefulness of exasomes as a non-invasive marker for diabetic renal disease pilot –study (2009-2011) (PI: Dr. Swasti Tiwari)

 

Extramural

 Prof. Swasti Tiwari

  • ICMR (2023-2026): Renal transcriptome regulation in diabetic kidney disease.
  • DBT (2019-2022): Title: Monitoring placental health & function across pregnancy using nanovesicles-full.
  • ICMR (2019-2024): Centre for Advance Research and Excellence on Kidney disease: Biomarkers and Therapeutics
  • DST (Indo- Israel) (2018-2020): Exploring therapeutic potential of exosomes in Type I diabetes mellitus.
  • DST (2018-2021), Role-Co-PI Umbilical cord mesenchymal stem cells derived exosomes as biogenic nanocarriers of miRNA and chemotherapeutic drug for reversal of chemoreistance in breast cancer.
  • DST-SERB (2018): International Symposium on Molecular Medicine 2018
  • UPCST (2017-2020) Effect of insulin signaling on tubular Albumin Reabsorption
  • ICMR (2017-2020)- Epigenetic modulation by statins in nephropathy
  • DST-SERB (2017-2020)- Role CO-PI: Medical Thermography and Gas Discharge Visualization technique: a diagnostic approach for type 2 diabetes based on non-contact infrared thermal imaging and Electro-photonic imaging: A multicentric study
  • DBT (2017-2019) Monitoring placental health & function across pregnancy using nanovesicles (pilot)
  • DBT (Completed in 2016) ‘Identifying renal repair and regeneration pathways using miRNA profiling’
  • DST (Completed in May 2015) Early diagnostic marker for diabetic nephropathy’
  • Department of Education, Ministry of HRD (2013-2021) Establishment of Centre of Excellence in Modern Biology
  • DBT (completed in August 2015) the causative role of reduced kidney-epithelial-cell insulin receptor in hypertension.

Dr. Alok Kumar

  • ANRF (2024-2027): Deciphering the role of novel class of hepcidin regulating biologics in restoration of autophagy flux and microglia/macrophage activation following JE viral infection Duration: 2024-2027 Role: Principal Investigator
  • DHR (2022-2025): Role of human umbilical cord mesenchymal stromal cells (hucMSCs) derived exosomes in CNS drug delivery molecules for the modulation of chronic neuroinflammation, pain-related behavior and motor function in the young injured brain.
  • DBT (2022-2025): Determination and establishment of key molecular therapeutic approach for remodeling of pericardial heart valve of Tetralogy of Fallot.
  • ICMR (2023-2026): Establishment of microparticle as a liquid biopsy tool for post-traumatic stress disorders (PTSD).
  • DBT (2017-2022): Autophagy regulation of microglia/ macrophage activation followed by Japanese encephalitis viral infection.

Dr. Lokendra Kumar Sharma

  • ICMR-Investigator Initiated Small Research Grant 2026-2029: Investigation of Mitochondrial Signatures as Noninvasive Biomarkers and Their Pathogenic Implications in Endometriosis. (Role-PI)
  • ICMR-Investigator Initiated Research Grant 2024-2027: Development of patient derived organoid bio- bank as a resource for drug response studies and precision medicine applications in triple negative breast cancer. (Role-PI)
  • Department of Health Research-2023-2026: Investigation of mitochondrial damage associated molecular patterns as potential biomarkers for pregnancy complications. (Role-PI):
  • Core Research Grant-SERB-DST- 2022-2025: Exploring the impact of an osteoblast-like cell subpopulation differentiated from breast cancer cells on tumorigenic activity and its possible therapeutic potential. (Role: Co-PI)
  • ICMR (2020-2023): Targeting mitophagy in breast carcinogenesis through mitochondrial-mediated mechanisms. (Role-PI):
  • DST (2019-2022): Investigation of metastatic potential of mitochondria and associated mechanisms using trans-mitochondrial cybrids. Funded by SERB-Department of Science & Technology. (Role-PI)

Dr. Santosh Verma

  • DBT, Govt. of India (2026-2029); Role-Project Coordinator and Principal Investigator; (Status: Sanctioned).
  • ICMR, Govt. of India (Jan2023-Jan2025): Role- Principal Investigator; (Status: Completed).
  • SERB-CRG, Govt. of India (2022-2025): Role- Principal Investigator; (Status: Completed).
  • DBT, Govt. of India (2020-2023); Role-Project Coordinator and Principal Investigator; (Status: Completed).

      Dr. Suman Mishra

  • ANRF, ECRG (2024-2027), Development and validation of trophoblast organoid model system for understanding the complexity of early placental development.
  • DBT BioCare (2023-2026); To identify IUGR-associated mitochondrial genes and their role in early pregnancy.